This category is a heterogeneous group of disorders that can affect emotional regulation, cognition, and behavior. Among others, such conditions as major depressive disorder, anxiety, bipolar disorder, and schizophrenia are characteristic of complex biopsychosocial processes involving the interaction of genetic and neurochemical factors with environmental aspects. The Addiction World Conference represents the most significant scientific forum for the discussion of mutual interrelations and patterns in such areas as mental health, addictions, and systemic diseases. The conference will assemble leaders in psychiatry, neuroscience, and addiction medicine and generate innovative ideas to advance therapeutic paradigms and translate discoveries into actionable resources for individuals with co-occurring conditions.