Psychoactive drugs fundamentally alter the way that brains work, affecting mood, perception, and action. While prescribed therapeutically for many in an expertly controlled setting, misuse can be pathologically associated with addiction, brain impairment, and bodily harm. Experts worldwide will be confronted with these issues and cutting-edge solutions at Addiction World Conference AWC 2025, focused on new advances in the science of addiction. This will inspire and empower the participants of the outstanding conference in Boston, USA, from September 5 to 7, 2025, offering valuable insights into the ever-changing challenges of psychoactive drug use and treatment.