Background The use of amphetamine- substances or ecstasy is widespread among young people across Southeast Asia, and particularly in Thailand. When used over long periods of time, amphetamines can induce cravings, depression, aggressive behavior or mental health problems. Forty -male patients engaged in two different 40 mins exercise groups (1) light- exercise with less supervision (2) circuit training with close supervision. The participants blood were withdrawn for protein BDNF analysis and MMSE were given on day 1and day 31. The results showed the cognitive function improved in light aerobic exercise.