With more than 5 years of experience and more than 5,000 patients treated, Clínica Pellet Chile decided to develop in Chile a subcutaneous implant of Disulfiram and Naltrexone for the treatment of alcoholic patients, users of cocaine and its derivatives and to a lesser extent opioids. This technology has been tested for approximately 5 years, in which both positive and negative results have been described. The implantation process, its effects and complications are described. In addition to offering as a real possibility of treatment.