5th Edition of Addiction World Conference 2026
Speakers - AWC 2024
Pirouz Daftarian
Pirouz Daftarian
- Designation: MBL International and Volunteer Faculty of University of Miami
- Country: USA
- Title: Vaccination Against Cocaine Using a Nanoparticle Platform Decorated with Universal T helper Epitope
Abstract
Dendrimers decorated with the HLA-DR epitope, PADRE, comprise a vaccine platform (PDD). This modified platform can deliver high quantities of conjugated cargo specifically to MHC class II-expressing antigen-presenting cells (APCs), including dendritic cells, macrophages, and B cells of multiple species. Here, the PDD platform is conjugated to a hapten, cocaine, demonstrating durable anti-hapten immunity. PDD vaccine generates high-affinity cocaine antibodies without the need for an adjuvant. Adjuvant formulations of the PDD vaccine do not increase further anti-cocaine titer levels. PDD-elicited anti-cocaine antibody response attenuates the rewarding effects of cocaine in adult male Sprague-Dawley rats.
Addiction World Conference (AWC) 2026: Addiction Science and Care Enter a New Era
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